Obesity gives vent to many diseases such as type 2 diabetes, hypertension, and hyperlipidemia, being considered as the main causes of mortality and morbidity worldwide. The pathogenesis and pathophysiology of metabolic syndrome can well be understood by studying the molecular mechanisms that control the development and function of adipose tissue. In human body, exist two types of adipose tissue, the white and the brown one, which are reported to play various roles in energy homeostasis. The major and most efficient storage of energy occurs in the form of triglycerides in white adipose tissue while brown adipose tissue actively participates in both basal and inducible energy consumption in the form of thermogenesis. Recent years have observed a rapid and greater interest towards developmental plasticity and therapeutic potential of stromal cells those isolated from adipose tissue. The adipocyte differentiation involves a couple of regulators in the white or brown adipogenesis. Peroxisome proliferators-activated receptor-γ actively participates in regulating carbohydrate and lipid metabolism, and also acts as main regulator of both white and brown adipogenesis. This review based on our recent research, seeks to highlight the adipocyte differentiation.

Citations

Citations to this article as recorded by  

• ZNF217: An Oncogenic Transcription Factor and Potential Therapeutic Target for Multiple Human Cancers
  Yepeng Wang, Chao Ma, Xuekun Yang, Jun Gao, Zhigang Sun
  Cancer Management and Research.2024; Volume 16: 49.     CrossRef
• COBL, MKX and MYOC Are Potential Regulators of Brown Adipose Tissue Development Associated with Obesity-Related Metabolic Dysfunction in Children
  Sarah Abdul Majeed, Helene Dunzendorfer, Juliane Weiner, John T. Heiker, Wieland Kiess, Antje Körner, Kathrin Landgraf
  International Journal of Molecular Sciences.2023; 24(4): 3085.     CrossRef
• Identification of Biochemical Differences in White and Brown Adipocytes Using FTIR Spectroscopy
  DongHyun Shon, SeJun Park, SukJun Yoon, Yong Ko
  Applied Sciences.2022; 12(6): 3071.     CrossRef
• Bone marrow adipocytes drive the development of tissue invasive Ly6Chigh monocytes during obesity
  Parastoo Boroumand, David C Prescott, Tapas Mukherjee, Philip J Bilan, Michael Wong, Jeff Shen, Ivan Tattoli, Yuhuan Zhou, Angela Li, Tharini Sivasubramaniyam, Nancy Shi, Lucie Y Zhu, Zhi Liu, Clinton Robbins, Dana J Philpott, Stephen E Girardin, Amira Kl
  eLife.2022;[Epub]     CrossRef
• Direct Conversion of Human Fibroblasts into Adipocytes Using a Novel Small Molecular Compound: Implications for Regenerative Therapy for Adipose Tissue Defects
  Yoshihiro Sowa, Tsunao Kishida, Fiona Louis, Seiji Sawai, Makoto Seki, Toshiaki Numajiri, Kenji Takahashi, Osam Mazda
  Cells.2021; 10(3): 605.     CrossRef
• The Role of Peptide Hormones Discovered in the 21st Century in the Regulation of Adipose Tissue Functions
  Paweł A. Kołodziejski, Ewa Pruszyńska-Oszmałek, Tatiana Wojciechowicz, Maciej Sassek, Natalia Leciejewska, Mariami Jasaszwili, Maria Billert, Emilian Małek, Dawid Szczepankiewicz, Magdalena Misiewicz-Mielnik, Iwona Hertig, Leszek Nogowski, Krzysztof W. No
  Genes.2021; 12(5): 756.     CrossRef
• Critical roles of microRNA-196 in normal physiology and non-malignant diseases: Diagnostic and therapeutic implications
  Milad Bastami, Andrea Masotti, Zahra Saadatian, Abdolreza Daraei, Mojtaba Farjam, Ali Ghanbariasad, Sepideh Zununi Vahed, Shirin Eyvazi, Yaser Mansoori, Ziba Nariman-Saleh-Fam
  Experimental and Molecular Pathology.2021; 122: 104664.     CrossRef
• Whole genome sequencing reveals a complex introgression history and the basis of adaptation to subarctic climate in wild sheep
  Maulik Upadhyay, Elisabeth Kunz, Edson Sandoval‐Castellanos, Andreas Hauser, Stefan Krebs, Alexander Graf, Helmut Blum, Arsen Dotsev, Innokentiy Okhlopkov, Alexey Shakhin, Vugar Bagirov, Gottfried Brem, Ruedi Fries, Natalia Zinovieva, Ivica Medugorac
  Molecular Ecology.2021; 30(24): 6701.     CrossRef
• microRNAs in Human Adipose Tissue Physiology and Dysfunction
  Alina Kurylowicz
  Cells.2021; 10(12): 3342.     CrossRef
• Multiple roles of HOX proteins in Metastasis: Let me count the ways
  Joy Jonkers, Priya Pai, Saraswati Sukumar
  Cancer and Metastasis Reviews.2020; 39(3): 661.     CrossRef
• Connectivity mapping of a chronic kidney disease progression signature identified lysine deacetylases as novel therapeutic targets
  Vanessa R. Williams, Ana Konvalinka, Xuewen Song, Xiaohua Zhou, Rohan John, York Pei, James W. Scholey
  Kidney International.2020; 98(1): 116.     CrossRef
• NOTCH Receptors and DLK Proteins Enhance Brown Adipogenesis in Mesenchymal C3H10T1/2 Cells
  María-Milagros Rodríguez-Cano, María-Julia González-Gómez, Beatriz Sánchez-Solana, Eva-María Monsalve, María-José M. Díaz-Guerra, Jorge Laborda, María-Luisa Nueda, Victoriano Baladrón
  Cells.2020; 9(9): 2032.     CrossRef
• Early-life programming of adipose tissue
  Ericka Moreno-Mendez, Saray Quintero-Fabian, Cristina Fernandez-Mejia, Maria-Luisa Lazo-de-la-Vega-Monroy
  Nutrition Research Reviews.2020; 33(2): 244.     CrossRef
• Nanotechnology‐Mediated Drug Delivery for the Treatment of Obesity and Its Related Comorbidities
  Yung‐Hao Tsou, Bin Wang, William Ho, Bin Hu, Pei Tang, Sydney Sweet, Xue‐Qing Zhang, Xiaoyang Xu
  Advanced Healthcare Materials.2019;[Epub]     CrossRef
• ZFP217 regulates adipogenesis by controlling mitotic clonal expansion in a METTL3-m6A dependent manner
  Qing Liu, Yuanling Zhao, Ruifan Wu, Qin Jiang, Min Cai, Zhen Bi, Youhua Liu, Yongxi Yao, Jie Feng, Yizhen Wang, Xinxia Wang
  RNA Biology.2019; 16(12): 1785.     CrossRef
• Regulation of Systemic Glucose Homeostasis by T Helper Type 2 Cytokines
  Yea Eun Kang, Hyun Jin Kim, Minho Shong
  Diabetes & Metabolism Journal.2019; 43(5): 549.     CrossRef
• DLK proteins modulate NOTCH signaling to influence a brown or white 3T3-L1 adipocyte fate
  María-Luisa Nueda, María-Julia González-Gómez, María-Milagros Rodríguez-Cano, Eva-María Monsalve, María José M. Díaz-Guerra, Beatriz Sánchez-Solana, Jorge Laborda, Victoriano Baladrón
  Scientific Reports.2018;[Epub]     CrossRef
• Norepinephrine triggers an immediate-early regulatory network response in primary human white adipocytes
  Juan Carlos Higareda-Almaraz, Michael Karbiener, Maude Giroud, Florian M. Pauler, Teresa Gerhalter, Stephan Herzig, Marcel Scheideler
  BMC Genomics.2018;[Epub]     CrossRef
• MicroRNAs and adipocytokines: Promising biomarkers for pharmacological targets in diabetes mellitus and its complications
  Mohamad Reza Ashoori, Mohammad Rahmati-Yamchi, Alireza Ostadrahimi, Sedigheh Fekri Aval, Nosratollah Zarghami
  Biomedicine & Pharmacotherapy.2017; 93: 1326.     CrossRef
• The Role of Peroxisome Proliferator-Activated Receptor Gamma (PPARG) in Adipogenesis: Applying Knowledge from the Fish Aquaculture Industry to Biomedical Research
  Rebecca Wafer, Panna Tandon, James E. N. Minchin
  Frontiers in Endocrinology.2017;[Epub]     CrossRef
• Recent progress in genetics, epigenetics and metagenomics unveils the pathophysiology of human obesity
  Marie Pigeyre, Fereshteh T. Yazdi, Yuvreet Kaur, David Meyre
  Clinical Science.2016; 130(12): 943.     CrossRef
• Metformin-suppressed differentiation of human visceral preadipocytes: Involvement of microRNAs
  Koji Fujita, Hisakazu Iwama, Kyoko Oura, Tomoko Tadokoro, Kayo Hirose, Miwako Watanabe, Teppei Sakamoto, Akiko Katsura, Shima Mimura, Takako Nomura, Joji Tani, Hisaaki Miyoshi, Asahiro Morishita, Hirohito Yoneyama, Keiichi Okano, Yasuyuki Suzuki, Takashi
  International Journal of Molecular Medicine.2016; 38(4): 1135.     CrossRef
• Platycodon grandiflorum A. De Candolle Ethanolic Extract Inhibits Adipogenic Regulators in 3T3-L1 Cells and Induces Mitochondrial Biogenesis in Primary Brown Preadipocytes
  Hye-Lin Kim, Jinbong Park, Hyewon Park, Yunu Jung, Dong-Hyun Youn, JongWook Kang, Mi-Young Jeong, Jae-Young Um
  Journal of Agricultural and Food Chemistry.2015; 63(35): 7721.     CrossRef
• New genetic loci link adipose and insulin biology to body fat distribution
  Dmitry Shungin, Thomas W. Winkler, Damien C. Croteau-Chonka, Teresa Ferreira, Adam E. Locke, Reedik Mägi, Rona J. Strawbridge, Tune H. Pers, Krista Fischer, Anne E. Justice, Tsegaselassie Workalemahu, Joseph M. W. Wu, Martin L. Buchkovich, Nancy L. Heard-
  Nature.2015; 518(7538): 187.     CrossRef
• Oxidative stress, redox regulation and diseases of cellular differentiation
  Zhi-Wei Ye, Jie Zhang, Danyelle M. Townsend, Kenneth D. Tew
  Biochimica et Biophysica Acta (BBA) - General Subjects.2015; 1850(8): 1607.     CrossRef
• Nutraceuticals and regulation of adipocyte life: Premises or promises
  Monica Colitti, Stefano Grasso
  BioFactors.2014; 40(4): 398.     CrossRef
• BMP and activin membrane-bound inhibitor (BAMBI) inhibits the adipogenesis of porcine preadipocytes through Wnt/β-catenin signaling pathway
  Yin Mai, Zhenyu Zhang, Hao Yang, Peiyue Dong, Guiyan Chu, Gongshe Yang, Shiduo Sun
  Biochemistry and Cell Biology.2014; 92(3): 172.     CrossRef
• The HOX genes network in metabolic diseases
  Alfredo Procino, Clemente Cillo
  Cell Biology International.2013; 37(11): 1145.     CrossRef